Dr Paul Brennan

Dr Paul Brennan

BMedSci(Hons), MBBS, FRCP

Clinical Genetics

27 years of experience
18 years as a specialist
Video consultation available

Overall Rating

Overall
5
Bedside Manner
4.98
Explanation
5

Top feedback

“I found Dr Brennan very knowledgeable and one of the best Doctors I have ever seen. He instantly put me at ease and listened well and explained everything to me. The appointment was for my little boy and he spent time talking to him and examined him in a child friendly way that my child felt at ease. He even offered me advice on my Genetic condition. I felt both my son and my self were in safe hands. It is a breath of fresh air to find a Doctor who is trained well and knows his stuff, he can see your symptoms and makes you feel validated and not try and pass them off. I have recommended Dr Brennan to people in similar situations to myself. I booked privately to see him and would pay the fee ten times over for such medical excellence. I will definitely book regular reviews with him as I feel I am getting a medical service far superior to what I had been used to, if you are like me and generally leave appointments feeling upset and not listened too , he is the Doctor for you. Thank you very much, this appointment has changed my little boys life for the better. “
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Languages spoken

  • English
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Registered with

  • General Medical Council: 3677959
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    Consultation fees

    New appointment: £350

    Follow-up appointment: £250

    Practices worked at

    The Harley Street Clinic

    35 Weymouth Street, london, United Kingdom, W1G
    467 reviews

    About

    Dr Brennan's main areas of expertise are cancer, cardiac and endocrine genetics.

    His interest in genetics started as a medical student in the 1980s when the medical speciality of clinical genetics was in its infancy. After a research degree studying genes in the developing heart, he completed his medical training and undertook postgraduate training in adult medicine and paediatrics before specialist training in Clinical Genetics.

    Dr Brennan was appointed as an NHS Consultant in Clinical Genetics in 2002 with the Northern Genetics Service based in Newcastle upon Tyne. After opening a new satellite clinical genetics department in Middlesbrough, he was appointed to the role of Clinical Director of the Northern Genetics Service in 2008, managing a clinical and laboratory team providing genetics diagnostics for the population of North East England and North Cumbria.

    Dr Brennan has been Clinical Lead for Cardiac and Endocrine Genetics for the Northern Genetics Service since 2003; he was Clinical Lead for Cancer Genetics 2002 to 2020. 

    A particular interest is the use of new technology and novel clinical pathways to improve diagnosis and management for people living with rare inherited disease. Between 2014 and 2018 he was Clinical Programme Director for the North East & North Cumbria NHS Genomic Medicine Centre, overseeing the introduction of whole genome sequencing into routine care as part of the 100,000 Genomes Project. He is engaged in a number of collaborative research projects, all of which are focused on improving diagnosis and treatment.

    Dr Brennan is a keen and popular teacher and lectures to a wide range of undergraduate and postgraduate audiences in the UK and overseas. He teaches genetics for a week each year at Newcastle University's Medical School in Malaysia.

    www.genomics.expert


    Diseases, Medical Tests and Treatments

    Dr Brennan has a long experience of diagnosing and managing hereditary diseases in adults and young people. In addition to general genetic problems such as chromosome abnormalities and infertility, his specialist areas are:

    A. Inherited cardiovascular disorders, for example:

    • Brugada syndrome
    • Long QT syndrome
    • Familial hypertrophic and dilated cardiomyopathy
    • Arrhythmogenic right ventricular cardiomyopathy
    • Sudden unexplained death
    • Familial thoracic aortic aneurysm
    • Marfan syndrome, Loeys Dietz syndrome and Meester-Loeys syndrome
    • Vascular Ehlers Danlos syndrome

    B. Inherited connective tissue disorders, including

    • classical Ehlers Danlos syndrome
    • hypermobile Ehlers Danlos syndrome

    C. Inherited cancer syndromes, for example:

    • Hereditary breast/ovarian cancer
    • Cowden's disease
    • Lynch syndrome
    • Familial Adenomatous Polyposis
    • Hereditary leiomyomatosis / renal cell carcinoma syndrome
    • Birt Hogg Dube syndrome
    • Li Fraumeni syndrome

    C. Inherited endocrine syndromes, for example:

    • Familial paragangliomatosis
    • Von Hippel Lindau disease
    • Multiple endocrine neoplasis types 1 & 2 and familial medullary thyroid cancer)

    D. Inherited skin disorder, for example:

    • Hereditary skins cancers
    • Neurofibromatosis
    • Birt Higg Dube syndrome

     

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    Special interests

    • Cancer Genetics
    • Ehlers-Danlos Syndrome (EDS)
    • Breast Cancer
    • Cardiomyopathy
    • Colorectal Cancer
    • Down Syndrome
    • Duchenne Muscular Dystrophy
    • Fabry Disease
    • Hereditary Endocrine Syndromes
    • Huntington’s Disease
    • Hypermobility Syndrome
    • Loeys Dietz Syndrome
    • Marfan Syndrome
    • Muscular Dystrophy
    • Noonan Syndrome
    • Ovarian Cancer
    • Turner Syndrome
    Read more

    Education

    • Bachelor of Medical Science (Human Genetics) Newcastle University
    • Bachelor of Medicine and Bachelor of Surgery, Newcastle University

    Professional Qualifications:

    • MRCP (Edinburgh)
    • FRCP (London)
    Read more

    Reviews

    4.99 Overall Patient Trust rating
    Overall Experience
    Explanation
    Bedside Manner
    Ehlers-Danlos Syndrome (EDS)
    9/63
    Genetic Consultation
    9/63
    Clinical Genetics
    8/63
    Hypermobility Syndrome
    8/63
    ehlers-danlos syndrome (EDS)
    5/63
    Cancer Genetics
    3/63
    Dhlers-Danlos Syndrome (EDS)
    3/63
    Marfan Syndrome
    3/63
    Genetic Procedures
    2/63
    Hypermobile Ehlers-Danlos Syndrome
    2/63
    hEDS
    2/63
    Breast Cancer
    1/63
    Ehlers Danlos Syndrome
    1/63
    Ehlers-Danlos syndrome
    1/63
    Ehlers-Danloss Test
    1/63
    Fertility Investigations
    1/63
    Genetic Testing
    1/63
    Genetic Testing - Epilepsy
    1/63
    Heds
    1/63
    Hypermobile Ehlers Danlos Syndrome
    1/63
    Hyypermobile Ehler's Danlos
    1/63
    Male Infertility
    1/63
    SCA-6
    1/63
    Translocation
    1/63
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    Sort by:
    Overall
    (5/5)
    Explanation
    (5/5)
    Bedside Manner
    (5/5)
    Patient seen for:
    Ehlers-Danlos Syndrome (EDS)
    I found Dr Brennan very knowledgeable and one of the best Doctors I have ever seen. He instantly put me at ease and listened well and explained everything to me. The appointment was for my little boy and he spent time talking to him and examined him in a child friendly way that my child felt at ease. He even offered me advice on my Genetic condition. I felt both my son and my self were in safe hands. It is a breath of fresh air to find a Doctor who is trained well and knows his stuff, he can see your symptoms and makes you feel validated and not try and pass them off. I have recommended Dr Brennan to people in similar situations to myself. I booked privately to see him and would pay the fee ten times over for such medical excellence. I will definitely book regular reviews with him as I feel I am getting a medical service far superior to what I had been used to, if you are like me and generally leave appointments feeling upset and not listened too , he is the Doctor for you. Thank you very much, this appointment has changed my little boys life for the better.
    Read more
    Overall
    (5/5)
    Explanation
    (5/5)
    Bedside Manner
    (5/5)
    Patient seen for:
    Ehlers-Danlos Syndrome (EDS)
    It was a breath of fresh air to see Dr Brennan after years of medical problems and seeing countless doctors. Dr Brennan actually listened, was sympathetic, thorough and knowledgeable. As well as being able to give me a diagnosis he was able to explain why I have the problems I have and a way for me to move forward. I highly recommend him.
    Read more
    Overall
    (5/5)
    Explanation
    (5/5)
    Bedside Manner
    (4/5)
    Patient seen for:
    Cancer Genetics
    Dr Brennan, explained things clearly and the service was an efficient one. Overall, a good experience.
    Read more
    Overall
    (5/5)
    Explanation
    (5/5)
    Bedside Manner
    (5/5)
    Patient seen for:
    Hypermobility Syndrome Ehlers-Danlos Syndrome (EDS)
    Dr Brennan was lovely and really listened to me and my symptoms and put my mind at rest about some worries that I had, highly recommend
    Read more
    Overall
    (5/5)
    Explanation
    (5/5)
    Bedside Manner
    (5/5)
    Patient seen for:
    Fertility Investigations
    Dr Brennan was very clear and helpful in explaining our particular situation. We really appreciated his thoughtfulness in trying to break things down using analogies that made it a lot more understandable for us.
    Read more
    Overall
    (5/5)
    Explanation
    (5/5)
    Bedside Manner
    (5/5)
    Patient seen for:
    Marfan Syndrome
    Dr Brennan put my son at ease right from the outset of the appointment. He was engaging and highly professional. Thank you
    Read more
    Overall
    (5/5)
    Explanation
    (5/5)
    Bedside Manner
    (5/5)
    Patient seen for:
    Cancer Genetics
    The doctor had researched the issues pertaining to me from the referral and was able to give clear and structured advice
    Read more
    Overall
    (5/5)
    Explanation
    (5/5)
    Bedside Manner
    (5/5)
    Patient seen for:
    Translocation Genetic Consultation
    He explained things in simple terms and made a complicated subject a lot clearer.
    Read more
    Overall
    (5/5)
    Explanation
    (5/5)
    Bedside Manner
    (5/5)
    Patient seen for:
    Hypermobile Ehlers Danlos Syndrome Ehlers-Danlos Syndrome (EDS) Hypermobility Syndrome
    I saw Dr. Brennan at the Osborne Clinic in Newcastle upon Tyne to get his expert opinion on Hypermobile Ehlers Danlos Syndrome. My daughter had been diagnosed with this syndrome over 6 years ago and it took years to finally find out she had this . I thought for a long time I had this too and it was such a relief to eventually get my diagnosis while I could still get some help as I wasn’t getting anywhere either . Dr Brennan is so polite , caring and makes you feel so at ease . He has recommended several doctors for me to see regarding my health issues . I would highly recommend Dr Paul Brennan to anyone . I just wished my daughter and I had seen him sooner .
    Read more
    Overall
    (5/5)
    Explanation
    (5/5)
    Bedside Manner
    (5/5)
    Patient seen for:
    Ehlers-Danlos Syndrome (EDS)
    Very professional and patient doctor.Extremely accommodating helpful and patient with an excellent manner.
    Read more
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